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sialic acid acetylesterase : ウィキペディア英語版
sialic acid acetylesterase
Sialic acid acetylesterase (SIAE) is an enzyme that produces 9-O acetylated sialic acid e.g. in mammals. It down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance e.g. in mice.
Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.〔
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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